Selected Publications

2024

Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB

Rahbani JF*, Bunk J*, Lagarde DM, Samborska B, Roesler A, Xiao H, Shaw A, Kaiser Z, Braun JL, Geromella MS, Fajardo VA, Koza RA, and Kazak L. Cell Metabolism

2022

ADRA1A-Ga_q signalling potentiates adipocyte thermogenesis through CKB and TNAP

Rahbani JF, Scholtes C, Lagarde DM, Hussain MF, Roesler A, Dykstra CB, Bunk J, Samborska B, O’Brien SL, Tripp E, Pacis A, Angueira AR, Johansen OS, Cinkornpumin J, Hossain I, Lynes MD, Zhang Y, White AP, Pastor WA, Chondronikola M, Sidossis L, Klein S, Kralli A, Cypess AM, Pedersen SB, Jessen N, Tseng YH, Gerhart-Hines Z, Seale P, Calebiro D, Giguère V and Kazak L. Nature Metabolism

A brown fat-selective mechanism of mitochondrial calcium import?

Rahbani JF and Kazak L. Cell Metabolism

Creatine transport and creatine kinase activity is required for CD8+ T cell immunity

Samborska B, Roy DG, Rahbani JF, Hussain MF, Ma E, Jones RG, and Kazak L (2021). Cell Reports

2021

Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine

Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, Kazak L, and Spiegelman BM. Nature

Creatine kinase B controls futile creatine cycling in thermogenic fat

Rahbani JF, Roesler A, Hussain MF, Samborska B, Dykstra CB, Tsai L, Jedrychowski MP, Vergnes L, Reue K, Spiegelman BM, and Kazak L. Nature

Creatine mediates crosstalk between adipocytes and cancer cells to regulate obesity-driven breast cancer

Maguire OA, Ackerman SE, Aarthi MV, Marchildon F, Huang X, Kramer DJ, Szwed SK, Rosas-Villegas A, Gelfer RG, Turner LE, Ceballos V, Hejazi A, Samborska B, Rahbani JF, Dykstra CB, Luo J, Carroll TS, Jiang CS, Dannenberg AJ, Tersey SA, Mirmira RG, Kazak L, and Cohen P. Cell Metabolism

2019

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay LC, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, and Spiegelman BM. Nature Metabolism